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Your total hippocampus volume is within normal range (5.30 cm3, 0.31% ICV). The mild rightward asymmetry (+2.58%) is well within expected bounds, indicating healthy bilateral hippocampal structure.
The CA2-CA3 subfield shows notable rightward asymmetry (+22.27%), right at the upper bound of the expected range (-58.54% to +22.04%). This region is involved in social memory and pattern separation. The wide normal range reflects the inherent variability of this small structure.
Good News: Total hippocampal volume and most subfields are entirely normal. The CA2-CA3 asymmetry, while notable, is still within Winterburn protocol limits and may reflect natural lateralization rather than pathology.
CA1: Memory retrieval and spatial navigation - most vulnerable to hypoxia and an early Alzheimer's marker.
CA2-CA3: Social memory and pattern separation.
CA4-DG: Neurogenesis site - new memory formation and pattern separation.
SR-SL-SM: Synaptic connectivity layers between subfields.
Subiculum: Output hub connecting hippocampus to cortex.
Caveat: HIPS uses the Winterburn segmentation protocol for subfield boundaries. Subfield volumes are inherently more variable than total hippocampal volume due to the challenge of defining boundaries between adjacent cellular populations.